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What is Histamine

Histamine is a natural and important compound of the human body regulating blood pressure, the immune system and is involved in the nervous system. In general, the body is able to balance the histamine release. In allergic reactions excessive release of histamine is responsible for the allergic symptoms. In this case antihistamine may help to reduce the release of histamine. But histamine is also present in high concentration in certain foods. Another source of histamine may be your gut flora. Particularly when you have SIBOS (small intestinal bacterial overgrowth syndrome) with the participation of putrefaction flora.

What is Histamine Intolerance?

Healthy people have an enzyme called Diamine Oxidase (DAO) which is present in the gut and decomposes histamine ingested with food. 3% of the population have a genetically determined severe DAO deficiency leading to manifest histamine intolerance and around 20% have a milder form of histamine intolerance. In this case symptoms mainly depend on the amount of histamine ingested or if DAO inhibitors are present. A potent DAO inhibitor is alcohol. Many subjects only symptoms of histamine intolerance when they consume alcohol, particularly red wine. But also, certain medications are potent DAO inhibitors. Histamine intolerance can be caused by deficiency in vitamin B6, copper and inflammation of the intestinal mucosa.

Histamine Intolerance Test (DAO)

  • Use as a standalone test for histamine intolerance or add to other IgG food intolerance tests for a complete picture.
  • Used by GPs and clinicians in over 40 countries.
  • Conducted in specialized certified German labs.
  • Undertaken with medically validated ELISA test method.
  • Tested with blood serum for accuracy (food intolerance blood test).

Histamine intolerance

Most people are able to regulate histamine levels well because they produce the right number of certain enzymes (including DAO), which break down excessive histamine in food and prevent it from accumulating. However, if you don't produce enough DAO and you eat a meal rich in histamine, you are likely to get an allergic type of response.

Symptoms of histamine intolerance include:

  • Hayfever
  • Migraines
  • Dizziness
  • Gastrointestinal complaints
  • Tachycardia (fast heart rate), arrhythmia (irregular heartbeat)
  • Menstrual pain
  • Asthma
  • Depression
  • Itching, red skin

One simple test could identify the cause of these troubling symptoms and improve your quality of life. Better still, if you wish to test for more potential food sensitivities or delayed IgG intolerance, once you receive your results you can use the same blood sample.

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ImuPro
Food Sensitivity Test
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DNA-Based Metabolism Test
Histamine
Intolerance (DAO) Test
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Neurotransmitter Testing
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