Histamine is a natural and important compound of the human body regulating blood pressure, the immune system and is involved in the nervous system. In general, the body is able to balance the histamine release. In allergic reactions excessive release of histamine is responsible for the allergic symptoms. In this case antihistamine may help to reduce the release of histamine. But histamine is also present in high concentration in certain foods. Another source of histamine may be your gut flora. Particularly when you have SIBOS (small intestinal bacterial overgrowth syndrome) with the participation of putrefaction flora.