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Food Intolerance and Depression: The Gut-Brain Connection

Depression is a complex mental health condition influenced by many factors—neurochemistry, stress, hormones, gut health, and immune system activity. One lesser-known but growing area of interest is the role of food intolerance, especially IgG-mediated hypersensitivities, in mood regulation and mental well-being.

The Gut-Brain Axis

Your gut and brain are deeply connected through the gut-brain axis—a communication network involving the nervous system, hormones, and immune signals.

• When you eat foods that trigger an IgG immune response, your body may experience low-grade chronic inflammation.
• This inflammation can affect not only your gut but also your nervous system and brain function, contributing to mood disturbances, fatigue, and brain fog.

Chronic Inflammation and Mood

• Studies show that inflammatory cytokines (produced during immune reactions) can alter serotonin and dopamine levels, two neurotransmitters critical for mood balance.
• Ongoing inflammation from food intolerances may lead to:
• Depressed mood
• Low energy
• Sleep disturbances
• Reduced motivation
• Increased anxiety or irritability

 How IgG Testing Helps

The ImuPro test detects elevated IgG antibodies against specific foods that may be contributing to inflammation and mood symptoms.

By identifying and eliminating these trigger foods:

• Systemic inflammation may reduce
• Gut health may improve
• Neurotransmitter balance may stabilize
• Many individuals report improved mood, clearer thinking, and better emotional regulation